Nucleic Acid Synthesis
Medchemexpress LLC SAH-SOS1A TFA | 2896737-31-6 | 96.6% | 2301.55 | 10 MG
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. It binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). This compound directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
- Peptide-based SOS1/KRAS protein interaction inhibitor
- Binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, Q61H) with nanomolar affinity
- Directly and independently blocks nucleotide association
- Impairs cancer cell viability
- Inhibits MEK1/2, ERK1/2, and AKT phosphorylation
Medchemexpress LLC Abacavir hydroxyacetate | 1446418-48-9 | MFCD34470006 | 99.6% | 344.37 | C16H20N6O3 | 5 MG
Abacavir hydroxyacetate is a research-grade small molecule reported to be an orally active inhibitor of IL-20 and PRINS. It modulates immune responses and reduces skin cell proliferation in psoriasis models, making it suitable for studies of inflammatory skin disorders and pathway validation.
- Orally active inhibitor of IL-20 and PRINS.
- Useful for researching inflammatory skin disorders and psoriasis biology.
- Provides a characterized small-molecule tool for pathway and target validation.
- High stated purity (~99.6%) for reproducible experimental results.
- Available in small research pack sizes for preclinical studies.
Medchemexpress LLC 2'-O-Methylcytidine | 2140-72-9 | 99.71% | 257.25 | 100 MG
2'-O-Methylcytidine is an orally active 2'-substituted nucleoside that acts as an inhibitor of HCV replication with antiviral activity. It inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro by competing with substrate nucleoside triphosphate. The compound has shown antiviral activity against Hepatitis C virus infected human Huh7 AVA5 cells with an EC50 of 1.8 μM, and cytotoxicity against the same cells with a CC50 of >300 μM. In HBI10A cells, 2'-O-Methylcytidine inhibits HCV RNA replication with an IC50 value of 21 μM. Furthermore, in vivo studies demonstrated that 2'-O-Methylcytidine (16.6 mg/kg, p.o., daily for 7 days) reduced serum HCV RNA by 1.05 log10 copies/mL in chronically infected chimpanzees.
- Orally active 2'-substituted nucleoside.
- Inhibits HCV replication.
- Exhibits antiviral activity.
- Competitively inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro.
Cayman Chemical 6-thIo-2-DeoxygunosIn 5mg
A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
Medchemexpress LLC Nucleoside-analog-1 | 876707-99-2 | 95.0% | C9H9N5O5 | 2 MG
Nucleoside-Analog-1 is a click chemistry reagent. It contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Contains an azide group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Compatible with molecules containing alkyne groups
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC)
- Compatible with molecules containing DBCO or BCN groups
Medchemexpress LLC 6-methyluridine | 16710-13-7 | 99.0% | 258.23 g·mol⁻¹ | C10H14N2O6 | 10 MG
6-Methyluridine is a uridine analogue supplied for laboratory research use. It is provided as a characterized solid with high purity and defined molecular identity for use in biochemical, analytical, and synthetic applications; not for human or clinical use.
- High purity (99.0%) suitable for research applications.
- Identified by CAS number 16710-13-7 for unambiguous reference.
- Molecular formula C10H14N2O6 and molecular weight 258.23 g·mol⁻¹.
- Available in multiple pack sizes, including 10 mg quantities.
- Intended for biochemical and pharmacological research workflows.
Medchemexpress LLC Trifluridine | 70-00-8 | MFCD00006534 | 99.9% | C10H11F3N2O5 | 1 ML
Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor that suppresses DNA synthesis. It is an antiviral molecule used in research for HSV, rhabdovirus, and orthopoxvirus infections. Trifluridine induces cell apoptosis and autophagy. It also functions as an anticancer agent for studies involving metastatic colorectal cancer and gastrointestinal tumors.
- Irreversible and orally active thymidylate synthase inhibitor
- Suppresses DNA synthesis
- Antiviral for HSV, rhabdovirus, and orthopoxvirus infections
- Induces cell apoptosis and autophagy
- Functions as an anticancer agent for metastatic colorectal cancer and gastrointestinal tumors
- Inhibits proliferation in various cancer cell lines
- Shows antitumor activity in human colorectal intraperitoneal xenograft model
eMolecules 65358-15-8 | Medchem Express | Pseudothymidine | 1mg | 446257497 | HY-101969 | 242.231 | C10H14N2O5
Medchem Express | Pseudothymidine | 1mg | 446257497 | HY-101969 | 65358-15-8 | 242.231 | C10H14N2O5
Medchemexpress LLC Nucleoside-Analog-1 | 876707-99-2 | 95.0% | C9H9N5O5 | 100 MG
Nucleoside-Analog-1 is a click chemistry reagent containing an azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that have alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Click chemistry reagent with an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Undergoes strain-promoted alkyne-azide cycloaddition reactions
- Purity of 95.0%
- Molecular formula C9H9N5O5
- Appearance: White to off-white solid
- Related to anti-infection and cell cycle/DNA damage pathways
- Associated with disease areas like cancer, infection, and hepatitis C virus infection
Medchemexpress LLC Nucleoside-Analog-2 | 876708-01-9 | ≥95.0% | C9H11N5O6 | 50 MG
Nucleoside-Analog-2 is a 4'-Azidocytidine analogue that targets Hepatitis C virus (HCV) replication. It functions as a click chemistry reagent due to its Azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups.
- Can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Targets Hepatitis C virus (HCV) replication.
Abcam BrdU (5-bromo-2'-deo x yuridine), Thymidine analog, 500MG
BrdU (5-bromo-2'-deoxyuridine), a thymidine analog, naturally incorporates into proliferating cells. Labels DNA, a useful marker for the study of DNA synthesis. Decreases TTP pools in vitro. Antitumor and radiation-sensitizing agent. Active in vitro and in vivo. - Cited in over 75 publications - Purity > 98% - Solubility: Dimethylacetamide ~ 200 (mg/mL), soluble in water to 50 mM
The product is subject to the following: Abcam Restricted Use Statement
![Revvity Health Sciences Inc Guanosine 5'-triphosphate, [8-<sup>3</sup>H], (GTP,[<sup>3</sup>H])](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502105566.jpg-250.jpg)
Revvity Health Sciences Inc Guanosine 5'-triphosphate, [8-3H], (GTP,[3H])
Guanosine 5'-triphosphate, [8-3H], (GTP,[3H])
Medchemexpress LLC 5-Methylcytidine 5′-triphosphate trisodium | 327174-86-7 | >99.6% | 563.13 | 57 MG
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified nucleoside triphosphate. It can be used in replacing unmodified mRNA, which leads to an increase in translational properties and stability, and a reduction in innate immune responses in human and other mammalian cells.
- Modified nucleoside triphosphate
- Increases translational properties and stability
- Reduces innate immune responses in human and mammalian cells
Abcam Ribavirin, Antiviral nucleoside, 10MG
MW 244.21 g/mol, Purity >99%. A non interferon-inducing, broad spectrum antiviral nucleoside. Active metabolites interfere with viral replication. Shows antiviral activity against a number of viruses including Hepatitis C, influenza and polio.
The product is subject to the following: Abcam Restricted Use Statement
Abcam BrdU (5-bromo-2'-deo x yuridine), Thymidine analog, 5G
BrdU (5-bromo-2'-deoxyuridine), a thymidine analog, naturally incorporates into proliferating cells. Labels DNA, a useful marker for the study of DNA synthesis. Decreases TTP pools in vitro. Antitumor and radiation-sensitizing agent. Active in vitro and in vivo. - Cited in over 75 publications - Purity > 98% - Solubility: Dimethylacetamide ~ 200 (mg/mL), soluble in water to 50 mM
The product is subject to the following: Abcam Restricted Use Statement